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In a recent study on diabetic mice, a ketogenic diet improved mitochondrial function and capacity through its activation of PGC-1 and SIRT1.62 Further, administration of exogenous BHB was found to increase PGC-1 and mitochondrial copy number in rat kidneys.63 Human data on mitochondrial function are lacking, but we obtained skeletal muscle biopsies from physically active adults before and after a 12-week ketogenic diet and demonstrated that mitochondrial function and efficiency shifted towards fat oxidation while improving insulin sensitivity.64 Traditional concerns of a ketogenic diet on kidney function Common misconceptions about ketogenic diets related to kidney health include potential adverse effects on acidbase and electrolyte balance and risk for kidney stones
Obesity , 30 (1), 1427
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Isoquercitrin, another active ingredient of MO, can strongly inhibit viral gene expression by attenuating the activation of the nuclear factor kappa (NF-B) signaling pathway (Vongsak et al., 2015)
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