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In healthy participants receiving test meals composed of sucrose and acarbose or voglibose, this approach was highly effective, whereas in studies more realistically copying the ingestion of meals in patients with type 2 diabetes, the effects were rather small or completely negligible [59]

With respect to the wider GLP-1 drug class, the UK SmPCs for semaglutide (available on the electronic Medicines Compendium, emc) and tirzepatide (Mounjaro SmPC, emc) document GI adverse effects including nausea, vomiting, diarrhoea, constipation, and dyspepsia as well-characterised class effects

Fatigue Semaglutide fatigue affects approximately 11% of users, and it tends to follow a different pattern than the gastrointestinal symptoms

What Does the Data Say About Weight Regain After Stopping