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HFpEF is characterized by the presence of different comorbidities such as type-2 diabetes mellitus (T2DM), visceral obesity and ageing, all contributing to systemic metabolic inflammation [7, 8]
Cell 141 , 290303 (2010)
The trade-off is practical: MK-677 is oral, requires no injection skill, costs less, and produces faster visible changes that make compliance easier in human trials
Subcutaneous administration in normal and metabolically dysregulated mice significantly inhibits NNMT activity in metabolically active tissues (adipose, liver, muscle), increases systemic NAD+ levels, enhances mitochondrial function, and improves energy metabolism
It targets only GLP-1 receptors and is administered once weekly via injection, though oral formulations also exist
