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Overall, those data suggest that the combined presence of several variant alleles of folate pathway genes is likely to increase significantly the maternal risk of birth of a child with DS

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This study was supported by Cancer Research UK Early Detection project grant (C476/A27060), Prostate Cancer UK awards (RIA-ST2-024 and MA-CT20-006), The Rosetrees Trust and John Black Foundation Charitable Trust (PhD-Plus award PhD2021-100025), Oxford University Human Immune Discovery Initiative (HIDI) fund, and UCARE-Oxford (GR280519)