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We lack data on conception timing (whether exposure just before pregnancy matters versus exposure during early pregnancy)

[PMID: 32562683] doi: 10.1016/S1474-4422(20)30173-3 Nrgaard CH , Friedrich S , Hansen CT , et al

All melanocortin receptors are class A G-protein-coupled receptors signalling principally through Gs and adenylyl cyclase to raise intracellular cAMP, and MC4R is the subtype whose ligand-bound active-state architecture is best resolved, including a 2021 cryo-EM series that captured bremelanotide bound to full-length MC4R in complex with heterotrimeric Gs