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Semaglutide, by contrast, binds GLP-1 receptors in the brain and gut to reduce hunger signals, lower blood sugar, and promote satiety

In the SURPASS-2 clinical trial, Mounjaro demonstrated greater HbA1c reductions compared to semaglutide 1 mg, with mean reductions of up to 2.3% (25 mmol/mol) from baseline at the 15 mg dose

Semaglutide was granted approval by the FDA in early 2023 as an obesity treatment in pediatric populations aged 12 and above [6, 7]

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Second, the approach marries a macroscopic trend (full sample) with microscopic validation (core sample), creating a breadth-depth double check that markedly strengthens inference