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Individual responses and safety profiles can vary significantly, and long-term human safety data beyond 30 days do not exist in the peer-reviewed literature outside the Russian registered indications
In the STEP 1 trial, semaglutide led to an average 14.9% reduction in body weight over 68 weeks , far outperforming placebo (NEJM study on semaglutide for weight loss)
These figures matter because they reflect how consistently the compound works across different individuals, not just how well it works for the average participant
The human liver stores enough vitamin B12 in the body to last for up to two years in most cases
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