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The SUSTAIN and STEP trial programs, which established semaglutide's efficacy for diabetes management and weight loss respectively, did not identify specific safety concerns related to concomitant blood thinner use
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Next came tirzepatide (Zepbound and Mounjaro), which acts on GLP-1 as well as GIP (glucose-dependent insulinotropic polypeptide), a second gut hormone
Despite the mixed outcomes on progression-free survival, the overall survival signal in a disease that has seen little meaningful progress in decades makes the program worth keeping an eye on in 2026
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