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These severe deficiencies manifest in a spectrum of debilitating symptoms, including but not limited to tinnitus, intense joint pain, cognitive impairment, mood disorders like depression and anxiety, muscle dysfunction, ataxia, and alterations in reflex responses

Vitamin D for Mood: Vitamin D supplementation can benefit those dealing with mood fluctuations or limited sun exposure

Genetic analyses have indicated a correlation between early-onset PD and mutations in the SLC2A9 gene, which exhibits a significant correlation with lower circulating UA levels [26]

Variants in the GLP1R gene (e.g., rs6923761) affect receptor sensitivity and signaling efficiency

The expansion of BMAT under conditions such as caloric restriction may also play a role by altering the bone marrow niche and inhibiting osteoblastogenesis through adipocyte-derived cytokines