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Nausea from tirzepatide Nausea is the most common complaint, affecting up to one-third of tirzepatide users at higher doses

The compound inhibits the NNMT enzyme in fat cells, which increases cellular NAD+ levels and shifts adipocyte metabolism from fat storage to fat burning

Contraindications include Lebers hereditary optic neuropathy, severe kidney disease, known cobalt or cobalamin allergy, and polycythemia vera

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