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Since GLP-1 RAs are often prescribed to patients with obesity, this single unmeasured factor could be the true driver of the observed risk. Demetrios Vavvas, MD, PhD Second, the results may be influenced by surveillance bias, Vavvas continued

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(PubMed) Together, these studies demonstrate that semaglutide in rats exerts broad systemic effects: appetite suppression via central neural pathways, altered feeding behaviour, favourable metabolic remodelling in tissues (including cardiac tissue), and clearly defined pharmacokinetic parameters

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