By midlife, NAD+ can drop by 50%, exacerbated by inflammation and lifestyle.[14] Factors like poor diet, sedentary behavior, or chronic stress further deplete NAD+ by activating consuming enzymes, creating a vicious cycle
[3] Initial dosing for moderate vasomotor symptoms typically ranges from 1 mg to 5 mg intramuscularly every three to four weeks, with some clinicians favoring a midpoint 2.5 mg monthly regimen and titrating upward or downward according to symptom relief and serum estradiol targets
I make no pretence that this article is a definitive history of this condition and 2) I have used the UK spelling of anaemia throughout, knowing that for those of you in the USA you will want it to say anemia and those of you in other countries might want me to call it Addision-Biermers, auto-immune gastritis, B12 malabsorption or B12 deficiency
Ive done 4 treatments and have been pain FREE for five days
However, the NHS provides a general recommendation of about 1.5g per day of B12 for adults