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In a previous double-blind placebo-controlled phase II trial, 42 self-sufficient subjects (with a score of 3+ on the ALSFRS-R items for swallowing, cutting food and handling utensils, and walking) with ALS [10] received ALCAR 3 g/day and 40 received placebo in an equivalent dose, and were followed for 12 months or until death [11]

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This exercise-induced oxidative stress can temporarily deplete glutathione as the antioxidant system works to neutralize the increased free radical production

The mitochondrial pyruvate carrier regulates memory T cell differentiation and antitumor function

[2] During a monotherapy clinical trial of topiramate in the treatment of epilepsy in adults, chest pain (unspecified) was reported in 1% of patients receiving 50 mg/day and 2% of patients receiving 400 mg/day