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There are no standard guidelines for getting off GLP-1s, so an individualized plan is crucial for minimizing weight gain and maximizing long-term health, Jaisinghani said

These medications can help suppress appetite, increase feelings of fullness, or inhibit the absorption of dietary fat

That restores the volume with fat-grafting, dermal fillers potentially, that resuspends, repositions, and removes any excess skin and replaces the soft tissue to its true position, and then also addressing the skin quality by reviving the skin whether that's through mechanisms such as radiofrequency, micro-needling or other things that improve the quality of the skin, Davidson said

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Procedures such as gastric bypass or sleeve gastrectomy have demonstrated significant long-term weight loss and improvement in obesity-related comorbidities, though patients require lifelong monitoring including thyroid function assessment, as malabsorption may affect levothyroxine requirements