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In keeping with this observation, here we unveil a crucial role of GSH in lipid production, as the synthesis of GSH, specifically in the liver, is required for sustaining physiological circulating triglyceride levels (an important energy source) and adipose tissue homeostasis under standard dietary regimen
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Persistent ROS generation or electrophilic stress can oxidize GSH to GSSG more rapidly than it is reduced, thereby depleting the reduced thiol pool
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Okoli GN et al
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