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GLP-1Rs are highly expressed in the LS and their signaling has been shown to attenuate the locomotor response to the psychostimulant d-amphetamine, 1 to reduce cocaine CPP, 14, 16 and to block self-administration for cocaine in rodents
Doctors still monitor for side effects, but to date, most tolerate it well
The original preclinical study used a GCGR antibody antagonist to isolate the GCGR contribution in DIO mice: GCGR blockade significantly blunted weight loss and blocked the LY3437943-induced increase in energy expenditure without affecting caloric-intake reduction
Medical weight loss is generally safe when done under the supervision of professionals
From host defense to metabolic signatures: unveiling the role of T cells in bacterial infections
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