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Elevated levels of triglycerides and free fatty acids in circulation are major factors driving lipid accumulation in the liver, leading to metabolic dysfunction-associated steatohepatitis (MASH) and liver fibrosis
Furthermore, ROS directly triggers the NF-B pathway [64], promoting the release of pro-inflammatory cytokines such as TNF-, IL-6, and IL-1 [65]
Gonzalez-Garcia I, Gruber T, Garcia-Caceres C
Tirzepatide activates GLP-1 and GIP hormones to manage appetite and boost metabolic health effectively
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