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Regulation of cell death: the calcium-apoptosis link
Key Highlights (72 weeks study): Resolution of steatohepatitis: 62.9% (semaglutide) vs 31.5% (placebo) Fibrosis improvement (1 stage): 36.8% vs 22.4% Average weight reduction: ~10% Better metabolic and liver markers Safety: Mostly mildmoderate GI side effects While semaglutide is not yet an approved antifibrotic, this data represents a major advancement in addressing both metabolic and hepatic components of the disease
The doses of GLP-1 provided by semaglutide and tirzepatide are far greater than the body would naturally expect to receive, he says, which may suppress the body's ability to secrete GLP-1 on its own
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