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corroborated by Oostdyk 2024) and downregulates surface GLP-1R within 12 hours at physiological albumin (Hinds 2024), so the sustained signal held against that fade, set by dose, is what carries the effect
Allen AP, Hutch W, Borre YE, Kennedy PJ, Temko A, Boylan G, et al
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Understanding the vicious circle of inflammation and how it alters the behavior of obese individuals, thereby worsening eating disorders and aggravating obesity, is essential
Thus, while consistent reductions in microvascular complications, combined with preclinical and observational evidence, strongly suggest a neuroprotective role for GLP-1 RAs, further focused research is needed to confirm their efficacy in preventing or slowing diabetic neuropathy progression
