Exenatide also had strong anhedonic effects in the same paradigms when injected directly into reward-related brain areas such as the ventral tegmental area (VTA), the nucleus accumbens (NAc), and even in the nucleus tractus solitarii (NTS), a structure previously thought to regulate homoeostatic feeding only [25,26,27,28,29]
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As shown in Figure 3B, 100 and 200 mg/kg cinchonine significantly reduced blood glucose at 15 min, and the AUC was also significant decreased compared with the mice gavaged with saline (Figure 3C)