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Initial studies in rats caused concerns over GLP-1 RAs causing thyroid cancer, but human studies are less clear on whether it is a concern.[ref] Decreased risk of substance abuse: A large 2026 study using data from the VA showed that GLP-1 RA drugs reduce the risk of developing a substance addiction (drugs, alcohol)
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My advice to clinicians is to proactively discuss contraception when initiating GLP-1 therapies in women of child-bearing age, document pregnancy intentions, and give pre-conception wash-out advice as per FSRH guidelines, said Dr Cheung
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