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d , Molecular dynamics simulation of compound 2 covalently bound to wild-type GLP-1R reveals unwinding of the N-terminal end of helix VI (IKC 6.36b RL, coloured orange) and re-organization of the ionic lock interaction network

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(2) personalized microbiomics: transitioning to customized medicine that accounts for an individuals unique GM profile, genetics, and lifestyle and (3) technological integration: utilizing AI and machine learning to predict therapeutic responses and leveraging CRISPR-based engineering to precisely modulate the microbial genome