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These side effects are usually mild to moderate and tend to improve over time with gradual dose escalation

cinerea strain B05.10 was used in this study

Biochemistry 50 , 618627 (2011)

Although some GLP-1RAs do not seem to naturally cross the bloodbrain barrier, they may still reach relevant brain areas via circumventricular sites and, possibly, via active transporters 4,5

While GLP-1 RA drugs are effective, their high cost ( US$1,350/month) and side effects (nausea, stomach pain, heartburn) raise concerns, especially about what happens after stopping treatment