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Removing the C-terminal domain by extensive proteolytic cleavage seems to be a prerequisite to convert the enzyme from its latent state into the active form

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The large phase 3 EVOKE trials in people who already had mild cognitive impairment or mild Alzheimers did not slow the disease, but the observational signal for prevention is strong, with real-world data from more than a million patients showing that semaglutide users have a 40 to 70 percent lower risk of a first Alzheimers diagnosis than users of other diabetes drugs

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