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This eliminates confounding from intensive lifestyle enrichment (STEP 3, SURMOUNT-3) and run-in/maintenance designs (STEP 4, SURMOUNT-4) that inflate active-arm weight loss estimates
Gastroenterology (2009) 137:164960
Mounjaro EPAR Public Assessment Report
But if the person is constantly lethargic, has swift weight gain or loss, an elevated heart rate, or is always sweaty, jittery, or nervous, the thyroid may be the culprit
For most patients, that warmth is transient, mild, and worth the trade-off given what it produces on the scale over 80 weeks
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