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Merck KGaA, Darmstadt, Germany), MS settings of the screening method used in 20202023 were switched to high-mass detection (m/z 7003,000) and the ESI-L LCMS Tuning Solution (Agilent Technologies) was used for calibration, whereas, in the screening method used in 2024 the data acquisition range was changed to m/z 1003,000, and a sodium iodide solution was used for MS calibration

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When p53 is inactivated, the accumulation of DNA damage leads to sustained senescence induction through p16 expression 29

Reduced Barrier to Entry: For certain types of research, particularly those involving less invasive methods or broader participant groups, an oral formulation could significantly lower the barrier to entry

doi: 10.1124/jpet.114.218735