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Whilst not a formal medical diagnosis or recognised adverse reaction, this phenomenon reflects the body contour changes that can accompany significant weight loss

It activates cytoprotective mechanisms within cells in a hormetic-type response

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Several studiesspanning a retrospective cohort analysis, a randomized pilot trial, a case series, and an international consensus commentaryoffer converging and sometimes contrasting evidence on how these therapies affect skeletal and lean tissue, along with practical strategies pharmacists and prescribers can discuss with patients