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doi: 10.1016/j.bbi.2019.11.006

MEK inhibitor AZD6244 induces cell growth arrest and synergizes with Nutlin-3a-mediated cell death by upregulating p53 and PUMA levels in AML

This enzyme converts glutamine into glutamate, which is then used for both ATP production through the citric acid cycle or glutathione synthesis, ultimately supporting cell proliferation and maintaining ROS homeostasis [174]

[17] Mar, M., Morales, A., Colell, A., Garca-Ruiz, C

Our APAP model [10] is simple because it does not include the processing of GSH in the mitochondria that has been shown to be fundamental for liver cell death in the presence of APAP [36]