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An Historical Review of Steps and missteps in the Discovery of Anti-obesity drugs
Its defining physicochemical feature is resistance to hydrolysis at low pH, unusual for a peptide of this length and attributed to a proline-rich, conformationally constrained backbone carrying three consecutive prolines plus a fourth at position eight
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Here is what the STEP trials tell us about side effects at 2.4 mg: Nausea: 43.9% of participants (vs
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