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But they were designed for insulin, not peptides, and this creates a translation challenge that confuses many researchers
What follows is the science behind that summary, drawn from the current FDA prescribing information for both products and from the one large trial that put them head to head
Expression and purification of Fab7F38 ExpiCHO-S cells (mouse, Chinese hamster ovary) were cultured in serum free ExpiCHO Expression Medium (Gibco)
Long-term fracture data on women who've been on semaglutide or tirzepatide for three or more years doesn't yet exist in published form
Last updated July 14, 2026 Key takeaways The current FDA Wegovy label, revised February 2026, gives injectable semaglutide an elimination half-life of approximately 1 week
