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They rarely control for diet, exercise, water weight, other compounds, camera conditions, or who chose to share a result
Carcinogenesis, Mutagenesis, Impairment of Fertility: Long term studies in animals to evaluate carcinogenic potential have not been done
see MIC Injections for typical timelines and schedules
Potential off-target effects: broad changes to methylation could, in theory, affect gene expression in ways not yet characterised
The 50 mg setup is far easier to draw accurately (20 units is a clean, mid-barrel mark) because the higher concentration and larger per-dose amount land on a bigger, more forgiving volume
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