Table 2 outlines the applications of the GHK peptide with larger bioactive peptides such as CyRL-QN15, LL-37, and AW1 across different wound healing models
Turan et al
This antioxidant potential has been studied in the gastrointestinal tract, where it may help counteract reactive oxygen species
These signaling events are commonly assessed using enzyme activity assays, phosphorylation analysis, and gene expression profiling in laboratory systems
This review integrates mechanistic insights with translational advances, outlining how dysregulation of chaperones, autophagy-mitophagy, the ubiquitinproteasome system, and ER stress pathways drive human diseases, while highlighting emerging therapeutic platforms, from pharmacological chaperones and autophagy modulators to targeted protein degradation technologies, CRISPR screens, spatial biology, and AI-guided drug discovery