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Gastrointestinal side effects are the most commonly reported and include: Nausea (affecting 1040% of patients, depending on the specific GLP-1 agonist) Vomiting and diarrhoea (less common than nausea but can contribute to dehydration) Constipation (due to slowed gastric emptying) Abdominal discomfort or bloating These effects are typically most pronounced during treatment initiation and following dose increases

It is worth highlighting that 15 GLP-1 drugs have been commercialized for targeting various indications

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Semaglutide drugs have been shown to increase the risk of eye strokes that cause vision loss

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