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doi: 10.1016/j.cmet.2024.05.008
Benefits: Increased strength and power output, improved muscle hydration, faster recovery
FDA approval applies to specific finished products manufactured under controlled conditions, not to the ingredient in general
Glucagon receptor activation has mixed cardiovascular effects, including some vasodilatory effects through cAMP signaling, balanced against the small heart rate increase The BP effects of retatrutide may include a small contribution from these direct mechanisms on top of the larger weight-loss-mediated effect
Ozempic (which contains semaglutide ) and Mounjaro (which contains tirzepatide ) are among the most well-known of this group
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