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(2) Plasma-membrane lipid bilayer: ROS attacks membrane PUFAs, driving lipid peroxidation and generating cytotoxic aldehydes such as malondialdehyde (MDA) and 4-hydroxynonenal (4-HNE), which compromise membrane integrity and fluidity and impair motility/fertilization-related functions
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Nevertheless, in a survey developed among 103 individuals of masculine sex, donors of the Blood Donation Point of the Colombian Red Cross and in appearance healthy, it was found a frequency of subnormal activity ( A nucleotide of exon 4 which results in the change of val for met, accompanied by the instability of the enzyme in vivo
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Circ Res 110(12):16461660 Haghighi K, Kolokathis F, Pater L, Lynch RA, Asahi M, Gramolini AO, Fan GC, Tsiapras D, Hahn HS, Adamopoulos S, Liggett SB, Dorn GW 2nd, MacLennan DH, Kremastinos DT, Kranias EG (2003) Human phospholamban null results in lethal dilated cardiomyopathy revealing a critical difference between mouse and human
