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The post presents this as context for expectations rather than a prediction of any one person's result

We'd split their dose

Participants who started at 4 mg without a lower starting dose reported fatigue more often than those who titrated up gradually from 2 mg

The prescribing clinician can use that baseline to decide whether a faster-than-typical titration, a slower one, or a tirzepatide-first approach is more likely to fit your biology before the first injection

Shapely can help patients access self-pay programs for FDA-approved medications, such as Wegovy through NovoCare and Zepbound through Lilly Direct, which may offer discounted pricing for eligible patients