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UMFA can accumulate when folic acid intake exceeds the bodys capacity to convert it into biologically active folate, particularly in individuals with reduced activity of the dihydrofolate reductase (DHFR) enzyme, which catalyses the first step in folic acid metabolism
Since semaglutide also reduces appetite and thirst signaling, many patients unconsciously drink less water, worsening the problem
With no more than 4 ounces of plain water
Journal of Clinical Endocrinology & Metabolism, 74: 292-298 Bowers (1998), Growth hormone-releasing peptide (GHRP)
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