FDAs 2023 Category 2 placement cited immunogenicity risk for certain routes of administration, peptide-related impurities, complexities in active pharmaceutical ingredient (API) characterization, and limited safety information for the proposed routes
At 8mg or 12mg weekly, the injection volume exceeds what a standard 1mL insulin syringe can hold
However, it also means that if you experience side effects or need to discontinue treatment, the medication's effects will persist for several weeks after stopping
Emerging modalities such as lysosomal-targeting chimeras, autophagy-targeting chimeras, and phosphorylation-inducing chimeras share analogous bifunctional designs and confront similar in vivo barriers [304,305,306,307]
Conflating them produces wildly inconsistent expectations