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Tesamorelin-specific human studies generally measure downstream hormone concentrations rather than directly sampling intracellular signaling inside pituitary somatotrophs

( PMID: 23324757 ) Benzaquen M, Borradori L, Berbis P, Cazzaniga S, Valero R, Richard MA, Feldmeyer L (2018) Dipeptidyl peptidase IV inhibitors, a risk factor for bullous pemphigoid: retrospective multicenter case-control study from France and Switzerland

Of three (3) major substrates available to it, cardiac muscle utilizes free fatty acid (FFA) as preferential substrate over glucose and lactate

They wait outside the mitochondria regardless of how much fat has been mobilized from adipose tissue into the bloodstream.

We prescribe CJC-1295/Ipamorelin and Tesamorelin instead, because both produce stronger and more sustained clinical effects than Sermorelin alone for adult growth hormone optimization