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The majority of events were reported as diabetic retinopathy (4%, 2.7%, and 2.7%, respectively) and non-proliferative retinopathy (0.7%, 0%, and 0%, respectively)
This process, known as freeze-thaw damage, often leads to aggregation and a catastrophic loss of biological activity
Oxidative stress has been widely recognized as a central pathophysiological mechanism involved in the development and progression of several vascular and rheumatic diseases [5,6,7,8] where the venous circulation becomes impaired
Some individuals might experience gastrointestinal disturbances, such as nausea or diarrhea, primarily due to the bodys reaction to the increased flow of bile and fat metabolism
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