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Recurrent moderate hypoglycemia accelerates the progression of Alzheimers disease through impairment of the TRPC6/GLUT3 pathway

Glucagon is a hormone produced by the pancreas in times of low blood sugar or stress, that stimulates the release of stored glucose from the liver and fat tissue

This approach not only facilitates the delivery of DSIP into the brain but also highlights the potential of brain-homing peptides as effective carriers for small molecule drugs, targeting brain parenchyma directly and efficiently

The company declared a boost in its R&D investment to $4.4 billion in 2022

Receptor desensitization and adaptation GLP-1 receptors can become temporarily desensitized when exposed to high agonist concentrations too quickly