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10.1016/j.pediatrneurol.2005.03.014 11

TLR4 and CD14 trafficking and its influence on LPS-induced pro-inflammatory signaling

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Notably, a similar phenomenon was observed in neurons from patients with MS, characterized by upregulated STING expression and markedly reduced STIM1 expression, suggesting that STIM1-STING-GPX4 axis-mediated ferroptosis is closely associated with neuronal injury in human MS pathology (Woo et al., 2024)