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Because these injections are not regulated by the FDA in the same way as medications, there can be variations in quality and composition

However, regulations differ by region

[5] Through gene regulation, estradiol promotes vaginal epithelial maturation, supports collagen synthesis within skin, and contributes to nitric-oxide-mediated vasodilation, collectively providing mechanistic explanations for clinical benefits such as improved vulvovaginal comfort and reduction in hot-flash frequency

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