however, comparing side by side the outcomes with regard to these end points in the three cardiovascular outcome studies with SGLT2 inhibitors (EMPA-REG OUTCOME, CANVAS Program, DECLARE-TIMI 58) and performing meta-analysis, it is clear that there is benefit across the class (Figures 3 and 4)
A recent RCT involving 731 HFpEF patients with obesity found that tirzepatide reduced the risk of the composite outcome of cardiovascular death or worsening heart failure compared to placebo (HR 0.62
You can start by aiming to go for a 5 minute walk after dinner, or in the morning, and gradually building up from there as it feels more comfortable
It works by mimicking the hormone GLP-1, which helps regulate appetite and food intake
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