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Derivatives of clinical novel inhibitors Despite the advances made in GLS inhibitors, the development of precursor drugs has encountered significant setbacks due to a lack of selectivity and low bioavailability

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In hepatocellular carcinoma models induced by DEN combined with either high-fat/high-carbohydrate or low-fat/low-carbohydrate diets, lean m/db mice, and MCD- or CDE-induced liver injuryas well as in human models, exenatide activation of the GLP-1RcAMPPKAEGFRSTAT3 pathway suppressed oncogenic signaling, limited tumor cell growth, and enhanced apoptosis, resulting in a marked reduction in tumor progression (Zhou et al., 2017)

Causing fat loss while maintaining muscle mass would therefore be an attractive feature of a novel therapeutic (Versanis bimagrumab may be differentiated here)