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When misfolded proteins are not adequately removed from cells, protein aggregation may occur, and these are hallmarks of some neurodegenerative diseases including Alzheimers (beta amyloid plaques) and Parkinsons (alpha synuclein-containing Lewy bodies)

In the context of critical limb ischemia (CLI) in murine models, TB-500 appears to have pro-angiogenic potential, as suggested by researchers

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GHK-Cu is sold as a research compound and is not FDA-approved for human use