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Based on these encouraging preliminary efficacy and safety signals, JSKN003 entered phase 3 trials in December 2023 (NCT06079983) [71]
Also, long-term usage of bronchodilators leads to various adverse effects including dry mouth, pupillary dilation, blurred vision, acute glaucoma, and cognitive dysfunction (Gupta and OMahony 2008)
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In hepatic IRI rats, pretreatment with SFN could alleviate liver injury by inhibiting oxidative stress and improving antioxidative activity as well as mitochondrial function in liver tissues, which was accompanied with the activation of Nrf2 pathway (Zhao et al., 2010
