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2024;12(1):e5516

503-515, Collins, Logan, and Ryan A

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Importantly, the sensitivity of the developed system matches physiologically relevant melatonin concentrations 41 , so that the system is switched OFF at daytime melatonin levels, while the increase of melatonin during the night-phase of the diurnal rhythm triggers robust transgene expression, effectively distinguishing between phases of the circadian rhythm cycle

This leads to the production of critical growth factors like vascular endothelial growth factor (VEGF), which promote new blood vessel formation and improve tissue oxygenation [7]