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Berberine commonly causes gastrointestinal distress including diarrhea, bloating, and abdominal discomfort in 10-30 percent of users, particularly at higher doses

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Average weight loss with Contrave is approximately 5-8% of body weight, lower than tirzepatide but meaningful for people whose weight gain is driven by emotional eating, food addiction, or reward-seeking behavior patterns

But I think the notion, I think it's the same for example with metformin, even though it gives less weight loss because that has also been tried in both people with diabetes and people without diabetes

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