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Chronic hyperglycemia is responsible for many complications, including cardiovascular disease, nerve damage (neuropathy), kidney damage (nephropathy), eye disease, unintentional weight loss (due to metabolism of fat and muscle, as cells do not have access to glucose to metabolize), and diabetic ketoacidosis

SCFAs bind to GPR43 and GPR41 and olfactory receptor 558 localized on EECs 281 and can regulate the number and activity of EECs 282,283

Human recombinant soluble ACE2 (hrs ACE2) shows promise for treating severe COVID19

It occurs in human plasma, saliva and urine, and its levels decline with age [1] [2]